5-Amino-1MQ is a small-molecule research compound studied as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in NAD+ and methyl-group metabolism. Unlike most products in Helix Bio's catalog, 5-Amino-1MQ is not a peptide — it's a quinolinium-based small molecule that reaches intracellular targets without receptor binding. Preclinical rodent studies have linked NNMT inhibition to adipocyte and fat-metabolism research outcomes, which is why the compound draws interest from researchers working alongside peptide-based metabolic compounds like MOTS-c and GLP-1-class peptides. Helix Bio supplies 5-Amino-1MQ as a research-grade powder intended strictly for laboratory use, manufactured to a high-purity standard and backed by third-party verification. It is not intended for human consumption, diagnostic use, or any therapeutic application.
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5-Amino-1MQ (5-amino-1-methylquinolinium) is studied as a selective, cell-permeable inhibitor of NNMT, an enzyme that methylates nicotinamide using S-adenosylmethionine (SAM) as a methyl donor. Because NNMT activity consumes both SAM and nicotinamide — the latter being a direct precursor to NAD+ — its inhibition is of interest to researchers studying NAD+ availability, methylation capacity, and adipose tissue metabolism. Published rodent work, most notably from the Kraus laboratory, reported reduced body weight, adipose mass, and adipocyte size in diet-induced obesity models following 5-Amino-1MQ administration, without a significant reduction in food intake.
Helix Bio's 5-Amino-1MQ is supplied as a research-grade powder — typically the iodide salt form, which is the standard reference material used across published research protocols. It's manufactured under controlled laboratory conditions and packaged to preserve stability during storage.
This product exists to support in vitro and preclinical laboratory research only. It's manufactured, labeled, and sold for research use only (RUO) — not for human or veterinary use, not for diagnostic procedures, and not for compounding. It's intended for researchers studying NNMT enzymology, NAD+ metabolism, or adipocyte and fat-metabolism research models.
5-Amino-1MQ sits in a different category than most of what Helix Bio sells — it's a small molecule rather than a peptide, and its research base comes from enzymology and rodent metabolic studies rather than human clinical trial programs. That makes sourcing verified, well-characterized material particularly important, since there's less published human data to cross-check a low-quality batch against. Helix Bio manufactures its 5-Amino-1MQ domestically, backs every batch with purity testing, and issues documentation so researchers can evaluate what they're working with before it reaches the bench. If your protocol calls for a small-molecule NNMT inhibitor to study alongside or against peptide-based metabolic compounds, that's what this listing is built around.
This product is not intended for individual consumers seeking to use it outside a research setting.
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