5-Amino-1MQ is a small-molecule research compound studied as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in NAD+ and methyl-group metabolism. Unlike most products in Helix Bio's catalog, 5-Amino-1MQ is not a peptide — it's a quinolinium-based small molecule that reaches intracellular targets without receptor binding. Preclinical rodent studies have linked NNMT inhibition to adipocyte and fat-metabolism research outcomes, which is why the compound draws interest from researchers working alongside peptide-based metabolic compounds like MOTS-c and GLP-1-class peptides. Helix Bio supplies 5-Amino-1MQ as a research-grade powder intended strictly for laboratory use, manufactured to a high-purity standard and backed by third-party verification. It is not intended for human consumption, diagnostic use, or any therapeutic application.
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5-Amino-1MQ (5-amino-1-methylquinolinium) is studied as a selective, cell-permeable inhibitor of NNMT, an enzyme that methylates nicotinamide using S-adenosylmethionine (SAM) as a methyl donor. Because NNMT activity consumes both SAM and nicotinamide — the latter being a direct precursor to NAD+ — its inhibition is of interest to researchers studying NAD+ availability, methylation capacity, and adipose tissue metabolism. Published rodent work, most notably from the Kraus laboratory, reported reduced body weight, adipose mass, and adipocyte size in diet-induced obesity models following 5-Amino-1MQ administration, without a significant reduction in food intake.
Helix Bio's 5-Amino-1MQ is supplied as a research-grade powder — typically the iodide salt form, which is the standard reference material used across published research protocols. It's manufactured under controlled laboratory conditions and packaged to preserve stability during storage.
This product exists to support in vitro and preclinical laboratory research only. It's manufactured, labeled, and sold for research use only (RUO) — not for human or veterinary use, not for diagnostic procedures, and not for compounding. It's intended for researchers studying NNMT enzymology, NAD+ metabolism, or adipocyte and fat-metabolism research models.
5-Amino-1MQ sits in a different category than most of what Helix Bio sells — it's a small molecule rather than a peptide, and its research base comes from enzymology and rodent metabolic studies rather than human clinical trial programs. That makes sourcing verified, well-characterized material particularly important, since there's less published human data to cross-check a low-quality batch against. Helix Bio manufactures its 5-Amino-1MQ domestically, backs every batch with purity testing, and issues documentation so researchers can evaluate what they're working with before it reaches the bench. If your protocol calls for a small-molecule NNMT inhibitor to study alongside or against peptide-based metabolic compounds, that's what this listing is built around.
This product is not intended for individual consumers seeking to use it outside a research setting.
| Field | Detail |
|---|---|
| Product Name | 5-Amino-1MQ |
| Category | Research Compound — Small-Molecule NNMT Inhibitor |
| Form | Powder (typically supplied as the iodide salt) |
| Purity | High-purity, batch-verified — see current lot's Certificate of Analysis for the exact figure |
| Appearance | White to off-white crystalline powder |
| Storage | Store in a cool, dry place, protected from light and moisture |
| Packaging | Sealed container, tamper-evident packaging |
| Research Use | Laboratory / in vitro / preclinical research only — not for human or animal use |
| Manufacturer | Domestically produced (USA) |
| Quality | Third-party purity testing performed per batch |
| Lot Testing | HPLC and mass spectrometry verification |
| Country of Origin | United States |
5-Amino-1MQ is studied across a few overlapping areas of enzymology and metabolic research:
As of mid-2026, published 5-Amino-1MQ research is limited to cell-culture and rodent studies — there are no published human clinical trials and no registered IND application on file with the FDA. NNMT itself is an active target across multiple academic and pharmaceutical research groups, but 5-Amino-1MQ specifically remains an investigational research compound with no clinical development program publicly announced. Everything sold by Helix Bio is intended for laboratory research only, not for administration to humans or animals outside a licensed research setting.
Purity is the first thing serious researchers check, and it's the first thing worth being transparent about. Helix Bio's 5-Amino-1MQ is manufactured in a controlled laboratory environment and tested by a third party using high-performance liquid chromatography (HPLC) and mass spectrometry — the two standard methods for confirming compound identity and purity in the research supply chain. Each batch is issued its own Certificate of Analysis (COA), so purity isn't something you have to take on faith; you can review the documentation for the specific lot you receive. If a vendor can't produce a COA for the batch in your hand, that's worth treating as a red flag — for 5-Amino-1MQ or any research compound.
Handling in our facility follows accepted good manufacturing practice for research-use compounds: material is processed to limit contamination, packaged in sealed, tamper-evident containers, and shipped in a way that protects powder integrity during transit.
5-Amino-1MQ ships in a sealed, tamper-evident container packaged to protect the powder in transit. Exact carriers, transit times, and packaging materials can vary by order — check Helix Bio's shipping policy page for current specifics before ordering.
5-Amino-1MQ sold by Helix Bio is intended strictly for in vitro laboratory and preclinical research use. It is not a drug, dietary supplement, cosmetic, or food product, and it is not approved by the FDA or any regulatory body for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease or condition. This product must not be administered to humans or animals outside of a properly licensed research facility. Nothing on this page constitutes medical advice, and no statement here should be interpreted as a therapeutic or health claim. References to published preclinical research are provided for research and educational context only and do not imply safety or efficacy in humans, which has not been established. By purchasing this product, the buyer confirms they are a qualified researcher, laboratory, or institution acquiring it for lawful research purposes only, and accepts full responsibility for compliance with all applicable local, state, and federal regulations governing research chemicals.
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